1997 & Order Publications

Highlights
* = co-first author, † = corresponding author
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Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

Wu H*, Myszda D G*, Tendian S W, Brouillette C G, Sweet R W, Chaiken I M, Hendrickson W A.  PNAS (1996). PDF

The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these proteins has been fully characterized... Read More

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Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein

Wu H, Lustbader J, Liu Y, Canfield R, Hendrickson W†. Structure (1994). PDF

Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by the placenta during the early weeks of pregnancy [1]. It stimulates the ovarian corpus luteum to produce progesterone until the placenta itself acquires the ability to produce this pregnancy sustaining steroid. Excess hCG is excreted... Read More

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Dimeric association and segmental variability in the crystal structure of human CD4

H Wu, P D Kwong, W A Hendrickson. Nature (1997). PDF

CD4 is a co-receptor in the cellular immune response. It increases the avidity of association between a T cell and an antigen-presenting cell by interacting with non-polymorphic portions of the complex between class II major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, and it contributes directly to signal transduction through its cytoplasmic association with the lymphocyte kinase... Read More

Other Publications (1997 & Order)
* = co-first author, † = corresponding author

Jiang X, Dreano M, Buckler D R, Cheng S, Ythier A, Wu H, W A Hendrickson, Tayar N E. (1995). Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 3:1341-1353

Lustbader J W, Wu H, Birken S, Pollak S, Kolks M A G, Pound A M, Austin D, Hendrickson W A, Canfield R E. (1995). The expression, characterization and crystallization of wild-type and selenomethionyl hCG. Endocrinology. 136:640-650

Lustbader J W, Wang C, Zhang X, Birken S, Wu H, Brown J M, Yarmush D, Pollak S, Canfield R E. (1994). Human chorionic gonadotropin: progress in determining its tertiary structure. Glycoprotein hormones. pp 81-102. Springer-Verlag, New York

Wu H, Keller W, Rossmann M G (1993). Determination and refinement of the canine parvovirus empty capsid structure. Acta Crystallogr. D49:572-579

Wu H†*, Rossmann M G.†* (1993). The canine parvovirus empty capsid structure. J Mol Biol. 233: 231-244

Tsao J, Chapman M S, Wu H, Agbandje M, Keller W, Rossmann M G. (1992). The structure determination of monoclinic canine parvovirus. Acta Crystallogr. B48:75-88

Rossmann M G†, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi H, Lynch R E. (1992). Molecular replacement real space averaging. J. Appl. Crystallogr. 25:166-180

Gong Z X, Wu H, Cheng R H, Hull R, Rossmann M G† (1990). Crystallization of cauliflower mosaic virus. Virology. 179:941-5