1997 & Order Publications

* = co-first author, † = corresponding author
wu kinetic.png

Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

Wu H*, Myszda D G*, Tendian S W, Brouillette C G, Sweet R W, Chaiken I M, Hendrickson W A.  PNAS (1996). PDF

The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these proteins has been fully characterized... Read More


Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein

Wu H, Lustbader J, Liu Y, Canfield R, Hendrickson W†. Structure (1994). PDF

Human chorionic gonadotropin (hCG) is a glycoprotein hormone secreted by the placenta during the early weeks of pregnancy [1]. It stimulates the ovarian corpus luteum to produce progesterone until the placenta itself acquires the ability to produce this pregnancy sustaining steroid. Excess hCG is excreted... Read More

wu dimer.png

Dimeric association and segmental variability in the crystal structure of human CD4

H Wu, P D Kwong, W A Hendrickson. Nature (1997). PDF

CD4 is a co-receptor in the cellular immune response. It increases the avidity of association between a T cell and an antigen-presenting cell by interacting with non-polymorphic portions of the complex between class II major histocompatibility complex (MHC) and T-cell receptor (TCR) molecules, and it contributes directly to signal transduction through its cytoplasmic association with the lymphocyte kinase... Read More

Other Publications (1997 & Order)
* = co-first author, † = corresponding author

Jiang X, Dreano M, Buckler D R, Cheng S, Ythier A, Wu H, W A Hendrickson, Tayar N E. (1995). Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 3:1341-1353

Lustbader J W, Wu H, Birken S, Pollak S, Kolks M A G, Pound A M, Austin D, Hendrickson W A, Canfield R E. (1995). The expression, characterization and crystallization of wild-type and selenomethionyl hCG. Endocrinology. 136:640-650

Lustbader J W, Wang C, Zhang X, Birken S, Wu H, Brown J M, Yarmush D, Pollak S, Canfield R E. (1994). Human chorionic gonadotropin: progress in determining its tertiary structure. Glycoprotein hormones. pp 81-102. Springer-Verlag, New York

Wu H, Keller W, Rossmann M G (1993). Determination and refinement of the canine parvovirus empty capsid structure. Acta Crystallogr. D49:572-579

Wu H†*, Rossmann M G.†* (1993). The canine parvovirus empty capsid structure. J Mol Biol. 233: 231-244

Tsao J, Chapman M S, Wu H, Agbandje M, Keller W, Rossmann M G. (1992). The structure determination of monoclinic canine parvovirus. Acta Crystallogr. B48:75-88

Rossmann M G†, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi H, Lynch R E. (1992). Molecular replacement real space averaging. J. Appl. Crystallogr. 25:166-180

Gong Z X, Wu H, Cheng R H, Hull R, Rossmann M G† (1990). Crystallization of cauliflower mosaic virus. Virology. 179:941-5