Hu JJ*, Liu X*, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H† (2020). FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation. Nature Immunology. doi: 10.1038/s41590-020-0669-6.

​

He M*, Chiang HH*, Luo H*, Zheng Z*, Qiao Q, Wang L, Tan M, Ohkubo R, Mu WC, Zhao S, Wu H, Chen D†.(2020). An Acetylation Switch of the NLRP3 Inflammasome Regulates Aging-Associated Chronic Inflammation and Insulin Resistance. Cell Metab. 31(3):580-591.

 

Wang L*, Negro R*, Wu H†(2020). TRPM2, linking oxidative stress and Ca2+ permeation to NLRP3 inflammasome activation. Curr Opin Immunol. 62:131-135.

​

Cui Y, Keles S, Charbonnier LM, Julé AM, Henderson L, Celik SC, Reisli I, Shen C, Xie WJ, Schmitz-Abe K, Wu H, Chatila TA† (2020). Combined immunodeficiency caused by a loss-of-function mutation in DNA polymerase delta 1. J Allergy Clin Immunol. 145(1):391-401.

 

Chen H*, Gu L*, Orellana EA, Wang Y, Guo J, Liu Q, Wang L, Shen Z, Wu H, Gregory RI, Xing Y, Shi Y† (2020). METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing. Cell Res doi: 10.1038/s41422-019-0270-4.

​

Lieberman J*†, Wu H*†, Kagan JC*†. Gasdermin D activity in inflammation and host defense. Sci Immunol. 4(39). pii: eaav1447. doi: 10.1126/sciimmunol.aav1447.

​

Sharif H*, Wang L*, Wang WL*, Magupalli VG, Andreeva L, Qiao Q, Hauenstein AV, Wu Z, Núñez G, Mao Y†, Wu H† (2019). Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome. Nature. 570(7761):338-343. 

​

Pan L*, Fu TM*, Zhao W*, Zhao L*, Chen W, Qiu C, Liu W, Liu Z, Piai A, Fu Q, Chen S†, Wu H†, Chou JJ† (2019). Higher-Order Clustering of the Transmembrane Anchor of DR5 Drives Signaling. Cell. 176(6):1477-1489.

​

Shen C*, Lu A, Xie WJ, Ruan J, Negro R, Egelman EH, Fu TM*†, Wu H*† (2019). Molecular mechanism for NLRP6 inflammasome assembly and activation.. Proc Natl Acad Sci U S A. 25(8):732-742.

​

Zhang P*, Fan Y*, Ru H, Wang L, Magupalli VG, Taylor SS, Alessi DR, Wu H*† (2019). Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 116(5):1579-1584.

​

Wang L*, Ferrao R*, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H† (2019). Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4). The Journal of biological chemistry. 2019.

​

Xia S*, Hollingsworth LR 4th*, Wu H†(2019). Mechanism and Regulation of Gasdermin-Mediated Cell Death. Cold Spring Harb Perspect Biol. pii: a036400. doi: 10.1101/cshperspect.a036400.

​

Wu H*, Arnold E* (2019). Michael G. Rossmann (1930-2019) Nat Struct Mol Biol. (8):660-662.

​

Wang L, Wu H† (2019). Keeping the Death Protein in Check. Immunity. 51(1):1-2.

​

Scott DA*† , Hatcher JM, Liu H, Fu M, Du G, Fontán L, Us I, Casalena G, Qiao Q, Wu H, Melnick A, Gray NS (2019). Quinoline and thiazolopyridine allosteric inhibitors of MALT1. Bioorg Med Chem Lett. 29(14):1694-1698.

​

Arnold E†* , Wu H*, Johnson JE*. (2019). Michael G. Rossmann (1930-2019), pioneer in macromolecular and virus crystallography: scientist, mentor and friend. Acta Crystallogr D Struct Biol. 75(Pt 6):523-527.

​

Xia S*, Wang L*, Fu TM†, Wu H† (2019). Mechanism of TRPM2 channel gating revealed by cryo-EM. FEBS J. 286(17):3333-3339.

​

Xia S, Ruan J†, Wu H†(2019). Monitoring gasdermin pore formation in vitro. Methods Enzymol. 625:95-107

​

Shen C, Sharif H, Xia S, Wu H† (2019). Structural and mechanistic elucidation of inflammasome signaling by cryo-EM. Curr Opin Struct Biol. 58:18-25

​

Lee YR, Chen M, Lee JD*, Zhang J*, Lin SY*, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP† (2019). Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway. Science. 364(6441).

​

Wang L*, Ferrao R*, Li Q, Hatcher JM, Choi HG, Buhrlage SJ, Gray NS, Wu H† (2019). Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). The Journal of biological chemistry. 294(12):4511-4519.

​

Choi YJ, Kim S, Choi Y, Nielsen TB, Yan J, Lu A, Ruan J, Lee HR, Wu H, Spellberg B, Jung JU†(2019). SERPINB1-mediated checkpoint of inflammatory caspase activation. Nature immunology. 20(3):276-287.

​

Mompeán M*, Bozkurt G*, Wu H†.(2019). Mimicry by a viral RHIM. EMBO reports. 20(2).

​

Wang L*, Fu TM*†, Zhou Y, Xia S, Greka A, Wu H† (2018). Structures and gating mechanism of human TRPM2. Science. 362(6421).

​

Li Y*, Fu TM*†, Lu A, Witt K, Ruan J, Shen C, Wu H† (2018). Cryo-EM structures of ASC and NLRC4 CARD filaments reveal a unified mechanism of nucleation and activation of caspase-1. Proc Natl Acad Sci U S A. 115(43):10845-10852.

​

Ru H*, Mi W*, Zhang P, Alt FW, Schatz DG, Liao M†, Wu H† (2018). DNA melting initiates the RAG catalytic pathway. Nature structural & molecular biology. 25(8):732-742.

​

Mompeán M*, Li W*, Li J*, Laage S, Siemer AB, Bozkurt G, Wu H†, McDermott AE† (2018). The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex. Cell. 173(5):1244-1253.

​

Ruan J, Xia S, Liu X, Lieberman J, Wu H† (2018). Cryo-EM structure of the gasdermin A3 membrane pore. Nature. 557(7703):62-67.

​

David L, Li Y, Ma J, Garner E, Zhang X, Wu H† (2018). Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome. Proc Natl Acad Sci U S A. 115(7):1499-1504

​

Ru H, Zhang P, Wu H (2018). Structural gymnastics of RAG-mediated DNA cleavage in V(D)J recombination. Curr Opin Struct Biol. 53:178-186.

​

Orning P, Weng D1*, Starheim K*, Ratner D*, Best Z, Lee B, Brooks A, Xia S, Wu H, Kelliher MA, Berger SB, Gough PJ, Bertin J, Proulx MM, Goguen JD, Kayagaki N, Fitzgerald KA, Lien E†.(2018). Pathogen blockade of TAK1 triggers caspase-8–dependent cleavage of gasdermin D and cell death Science. 362(6418):1064-1069.

​

Luong P, Hedl M, Yan J, Zuo T, Fu TM, Jiang X, Thiagarajah JR, Hansen SH, Lesser CF, Wu H, Abraham C†, Lencer WI †(2018) INAVA-ARNO complexes bridge mucosal barrier function with inflammatory signaling. eLife. 2018; 7.

​

Fontán L*†, Qiao Q, Hatcher JM, Casalena G, Us I, Teater M, Durant M, Du G, Xia M, Bilchuk N, Chennamadhavuni S, Palladino G, Inghirami G, Philippar U, Wu H, Scott DA*, Gray NS, Melnick A*† (2018). Specific covalent inhibition of MALT1 paracaspase suppresses B cell lymphoma growth. The Journal of clinical investigation. 128(10):4397-4412.

​

Feltham R*, Jamal K*, Tenev T*, Liccardi G, Jaco I, Domingues CM, Morris O, John SW, Annibaldi A, Widya M, Kearney CJ, Clancy D, Elliott PR, Glatter T, Qiao Q, Thompson AJ, Nesvizhskii A, Schmidt A, Komander D, Wu H, Martin S, Meier P† (2018). Mind Bomb Refulates Cell Deth during TNF Signalling by Suppressing RIPK1’s Cytotoxic Potential. Cell Rep. 23(2):470-484.

​

Annibaldi A †, Wicky John S*, Vanden Berghe T*, Swatek KN*, Ruan J, Liccardi G, Bianchi K, Elliott PR, Choi SM, Van Coillie S, Bertin J, Wu H, Komander D, Vandenabeele P, Silke J, Meier P †(2018). Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 69(4):566-580.

​

Xia S*, Fu TM*, Wu H† (2018). Inflammation NODs to Antagonists of RIP2-XIAP Interaction. Mol Cell. 69(4):535-536.

​

Fu TM*, Shen C*, Li Q, Zhang P, Wu H† (2018). Mechanism of ubiquitin transfer promoted by TRAF6. Proc Natl Acad Sci U S A. 115(8):1783-1788.

​

Zhang L, Wu H† (2018). Bad germs are trapped. Cell Res. 28(2):141-142

​

Evavold CL, Ruan J, Tan Y, Xia S, Wu H, Kagan JC† (2018). The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages. Immunity. 48(1):35-44

​

Wang L*, Qiao Q, Ferrao R*, Shen C, Hatcher JM, Buhrlage SJ, Gray NS, Wu H† (2017). Crystal structure of human IRAK1.​ Proc Natl Acad Sci U S A114(51):13507-13512

​

Qiao Q*, Wang L*, Meng FL, Hwang JK, Alt FW, Wu H† (2017). AID Recognizes Structured DNA for Class Switch Recombination. Mol Cell 67(3):361-373

​

Choi JY*, Qiao Q*, Hong SH, Kim CM, Jeong JH, Kim YG, Jung YK, Wu H†, Park HH† (2017). CIDE domains form functionally important higher-order assemblies for DNA fragmentation Proc Natl Acad Sci U S A114(28):7361-7366

​

Sharif H*, Li Y*, Dong Y, Dong L, Wang WL, Mao Y, Wu H† (2017). Cryo-EM structure of the DNA-PK holoenzyme. Proc Natl Acad Sci U S A114(28):7367-7372

​

Hauenstein AV*, Xu G, Kabaleeswaran V, Wu H† (2017) .Evidence for M1-Linked Polyubiquitin-Mediated Conformational Change in NEMO. J Mol Biol429(24):3793-3800

​

Kleino A, Ramia NF, Bozkurt G, Shen Y, Nailwal H, Huang J, Napetschnig J, Gangloff M, Chan FK*, Wu H*†, Li J†, Silverman N*†.(2017). Peptidoglycan-Sensing Receptors Trigger the Formation of Functional Amyloids of the Adaptor Protein Imd to Initiate Drosophila NF-κB Signalin. Immunity 47(4):635-647

​

Wang H, Feng Z, Lu A, Jiang Y, Wu H, Xu B† (2017). Instant Hydrogelation Inspired by Inflammasomes. Angew Chem Int Ed Engl.56(26):7579-758

​

Wang L, Qiao Q, Wu H†(2017). Understanding CARD Tricks in Apoptosomes. Structure. 25(4)575-577

​

Yi L, Bozkurt G, Li Q, Lo S, Menon AK, Wu H† (2017). Disulfide Bond Formation and N-Glycosylation Modulate Protein-Protein Interactions in GPI-Transamidase (GPIT). Sci Rep. 8:45912

​

Lamour G, Nassar R*, Chan PH*, Bozkurt G, Li J, Bui JM, Yip CK, Mayor T, Li H, Wu H, Jorg A. Gsponer† (2017). Mapping the Broad Structural and Mechanical Properties of Amyloid Fibrils. Biophys. 112(4):584-594

​

Katja G. Weinacht*†, Louis-Marie Charbonnier*, Fayhan Alroqi, Ashley Plant, Qi Qiao, Hao Wu, Clement Ma, Troy R. Torgerson, Serogo D. Rosenzweig, Thomas A.Fleisher, Luigi D. Notarangelo, Imelda C. Hanson, Lisa R. Forbes, Talal A. Chatila (2017). Ruxolitinib reverses dysregulated T helper cell responses and controls autoimmunity caused by a novel signal transducer and activator of transcription 1 (STAT1) gain-of-function mutation. Journal of Allergy and Clinical Immunology. 139(5):1629-1640

​

Fu TM*, Li Y*, Li Z, Vajjhala PR, Cruz AC, Srivastava DB, DiMaio F, Penczek PA, Siegel RM, Stacey KJ, Egelman EH, Wu H† (2016). Cryo-EM Structure of Caspase-8 Tandem DED Filament Reveals Assembly and Regulation mechanisms of the Death-Inducing Signaling Complex. Mol Cell. 64(2):236-250

​

Liu X*, Zhang Z*, Ruan J*, Pan Y, Magupalli VG, Wu H†, Lieberman J† (2016). Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores. Nature. 535:153-8

​

Wu H*†, Fuxreiter M*† (2016). The Structure and Dynamics of Higher-Order Assemblies: Amyloids, Signalosomes, and Granules. Cell. 165:1055-1066

​

Lu A*, Li Y*, Schmidt FI, Yin Q, Chen S, Fu TM, Tong AB, Ploegh HL, Mao Y, Wu H† (2016). Molecular basis of caspase-1 polymerization and its inhibition by a new capping mechanism. Nat Struct Mol Biol. 23(5):416-25

​

Schmidt FI*, Lu A*, Chen JW, Ruan J, Tang C, Wu H†, Ploegh HL† (2016). A single domain antibody fragment that recognizes the adaptor ASC defines the role of ASC domains in inflammasome assembly. J Exp Med. 213(5):771-90

​

Fu Q*, Fu TM*, Cruz AC, Sengupta P, Thomas SK, Wang S, Siegel RM, Wu H†, Chou JJ† (2016). Structural basis and functional role of intramembrane trimerization of the Fas/CD95 death receptor. Mol. Cell. 61:602-13

​

Janssen E*,Tohme M*, Hedayat M*, Leick M*,Kumari S, Ramesh N, Massaad M J, Ullas S, Azcutia V,  Goodnow C C, Randall K L, Qiao Q, Wu H, Al-Herz W, Cox D, Hartwig J, Irvine D J,  Luscinskas F W, and Geha RS† (2016). A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. The Journal of Clinical Investigation. 126(10)3837-3851

​​

Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado CA, Shao F, Wu H, Springstead JR, Kagan JC† (2016). An endogenous caspase-11 ligand elicits interleukin-1release from living dendritic cells. Science. 352:1232-6​

​

Myer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin A, Borek D, Brett TJ, Caflisch A, Chung-I C, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Cera ED, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D’Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJB, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P† (2016). Data publication with the structural biology data grid supports live analysis. Nature Communications. 7;7:10882

​

Ru H, Chambers MG, Fu T, Tong AB, Liao M† , Wu H† (2015). Molecular mechanism of V(D)J recombination captured by structures of RAG1-RAG2 synaptic complexes. Cell. 163:1138-52

​

Zhang L*, Chen*, Jianbin R, Wu J, Tong AB, Yin Q, Li Y, David L, Lu A, Wang WL, Marks C, Ouyang Q, Zhang X, Mao Y†, Wu H† (2015). Cryo-EM structure of the activated NAIP2/NLRC4 Inflammasome reveals nucleated polymerization. Science. 350:404-9

​

Yin Q*, Fu TM*, Li J, Wu H (2015). Structural Biology of Innate Immnuity. Annu. Rev. Immunol. 33:393-416

​

Qiao Q, Wu H† (2015). Supramolecular organizing centers (SMOCs) as signaling machines in innate immune activation. Sci China Life Sci. 58:1067-72

​

Vajjhala P, Lu A, Brown D, Pang S, Sagulenko V, Sester D, Cridland S, Hill J, Schroder K, Stow J, Wu H†, Stacey K†. (2015). The inflammasome adaptor ASC induces procaspase-8 death effector domain filaments. J Biol Chem. 290:29217-30

​

Lu A, Wu H† (2015). Structural Mechanism of Inflammasome Assembly. FEBS J. 282:435-444

​

Wu H*, Yokoyama S*, Lugar K*, Doudna J*, Wilson I*, Xu RM*. (2015). What’s your favorite crystal structure? Cell. 159:967-968

​

Lu A*, Li Y*, Qian Y, Ruan J, Yu X, Egelman E, Wu H†. (2015). Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discovery. 1, 15013

​

Onizawa M*, Oshima S*, Schulze-Topphoff U*, Oses-Prieto JA, Lu T, Tavares R, Prodhomme T, Duong B, Whang MI, Advincula R, Agelidis A, Barrera J, Wu H, Burlingame A, Malynn BA, Zamvil SS, Ma A†. (2015). The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIP3 and protects cells from necroptosis. Nature Immunology. 16:618-627

​

Wei S, Kozono S, Kats L, Nechama M, Li W, Guarnerio J, Luo M, You MH, Yao Y, Kondo A, Hu H, Bozkurt G, Moerke NJ, Cao S, Reschke M, Chen CH, Rego EM, Lo-Coco F, Cantley LC, Lee TH, Wu H, Zhang Y, Pandolfi PP, Zhou XZ†, Lu KP† (2015). Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer. Nat Med. 21:457-466

​

Hauenstein A*, Zhang L*, Wu H†. (2015). The hierarchical structural architecture of inflammasomes, supramolecular inflammatory machines. Curr Opin Struct Biol. 31:75-83

​

Kagan JC*†, Magupalli V*, Wu H*† (2014). SMOCs: supramolecular organizing centres that control innate immunity.​ Nature Rev Immunol. 14:821-6

​

Ferrao R, Zhou H, Shan Y, Liu Q, Li Q, Shaw DE, Li X, Wu H† (2014). IRAK4 Dimerization and the Trans-autophosphorylation are Induced by Myddosome Assembly. Mol Cell. 55:891-903

​

Lu A*, Magupalli VG*, Ruan J*, Yin Q, Atianand MK, Vos MR, Schröder GF, Fitgerald KA, Wu H†, Egelman EH (2014). Unified Polymerization Mechanism for the Assembly of ASC-Dependent Inflammasomes. Cell. 6:1193-206

​

Li L*†, Yin Q, Kuss P, Maliga Z, Millán JL, Wu H, Mitchison T*. (2014). Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs. Nat Chem Biol. 10:1043-8

​

Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH†. (2014). Structural Study of the RIPosptosome core reveals a helical assembly for kinase recruitment. Biochemistry. 53:5424-31

​

Ru H*, Zhang P*, Wu H†. (2014). Promiscuity is not Always Bad. Mol Cell. 2:208-9

​

Furman RR*, Cheng S*, Lu P*, Setty M, Perez AR, Guo A, Racchumi J, Xu G, Wu H, Ma J, Steggerda SM, Coleman M, Leslie C, Wang YL. (2014). Ibrutinib Resistance in Chronic Lymphocytic Leukemia. N Engl J Med. 24:2352-4

​

Lu A, Kavaleeswaran V, Fu T, Magupalli VG, Wu H†. (2014). Crystal Structure of the F27G AIM2 PYD Mutant and Similarities of Its Self-Association to DED/DED Interactions. J Mol Biol. 7:1420-7

​

Qiao Q*, Yang C*, Zheng C*, Fontan L, David L, Yu X, Bracken C, Rosen M, Melnick A, Egelman E, Wu H† (2013). Structural Architecture of the CARMA1/Bcl10/MALT1 Signalosome: Nucleation-Induced Filamentous Assembly.​ Mol Cell. 51:766-779

​

Yin Q*, Sester DP*, Tian Y*, Hsiao YS, Lu A, Cridlan JA, Sagulenko V, Thygesen SJ, Chouhey D, Hornung V, Walz T, Stacey KJ†, Wu H† (2013). Molecular Mechanism for p202-mediated Specific Inhibition of AIM2 Inflammasome Activation. Cell Reports. 4:327-39

​

Lee JH*, Yi L*, Li J, Schweitzer K, Borgmann M, Naumann M, Wu H† (2013). Crystal Structure and Versatile Functional Roles of the COP9 Signalsome Subunit 1. Proceedings of the National Academy of Sciences. 110:11845-50

​

Wu H† (2013). Higher-Order Assemblies in a New Paradigm of Signal Transduction. Cell. 153:287-292

​

Yang C†, David L, Qiao Q, Damko E, Wu H. (2013). The CBM Signalosome: Potential Therapeutic Target for Aggressive Lymphoma? Cytokine Growth Factor Rev. 2:175-183

​

Kim S*, Li L*, Maliga Z, Yin Q, Wu H, Mitchison T†. (2013). Anticancer Flavonoids Are Mouse-Selective STING Agonists. ACS Chemical Biology. 8:1396-1401

​

Li J*, Yin Q*, Wu H†. (2013). Structural Basis of Signal Transduction in the TNF Receptor Superfamily. Advanced Immunology. 119:135-53

​

Napteschnig J, Wu H†. (2013). Molecular Basis of NF-kB signaling. Annual Reviews in Biophysics. 42:443-68

​

Lu TT, Onizawa M, Hammer GE, Turer EE, Yin Q, Damko E, Agelidis A, Shifrin N, Advincula R, Barrera J, Malynn BA, Wu H, Ma A†. (2013). Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme. Immunity. 38:1-10

​

Fontan L*, Yang C*, Kabaleeswaran V, Volpon L, Osborne MJ, Beltran E, Garcia M, Cerchietti L, Shaknovich R, Yang SN, Fang F, Gascoyne RD, Martinez-Climent JA, Glickman JF, Borden K, Wu H†, Melnick A† (2012). MALT1 Small Molecule Inhibitors Specifically Suppress ABC-DLBCL In Vitro and In Vivo.​ Cancer Cell. 22:812-24

​

Yin Q†, Tian Y, Kabaleeswaran V, Jiang X, Tu D, Eck MJ, Chen ZJ, Wu H† (2012). Cyclic di-GMP sensing via the innate immune signaling protein STING. Mol Cell. 46:735-45

​

Li J, McQuade T, Siemer AB, Napetschnig J, Moriwaki K, Hsiao YS, Damko E, Moquin D, Walz T, McDermott A, Chan FK, Wu H† (2012). The RIP1/RIP3 necrosome forms a functional amyloid signaling complex required for programmed necrosis. Cell. 150:339-50

​

Ferrao R, Li J, Bergamin E, Wu H†. (2012). Structural insights into the assembly of large oligomeric signalosomes in the Toll-like receptor-interleukin-1 receptor superfamily. Sci Signal. 5:re3

​

Ferrao R, Wu H†. (2012). Helical assembly in the death domain (DD) superfamily. Curr Opin Struct Biol. 22:241-7

​

Feldman T, Kabaleeswaran V, Jang SB, Antczak C, Djaballah H, Wu H, Jiang X†. (2012). A class of allosteric caspase inhibitors identified by high-throughput screening. Mol Cell. 47:585-95

​

Xu G*, Lo YC*, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H† (2011). Crystal structure of inhibitor of kappaB kinase beta. Nature. 472:325-330

​

Wu H*, Siegel RM*. Medicine. (2011). Progranulin resolves inflammation. Science. 332:427-8

​

Zheng C*, Yin Q*, Wu H†. (2011). Structural studies of NF-kB signaling. Cell Research. 21:183-959

​

H Wu, YC Lo, Q Yin. (2011). Structural studies of NEMO and TRAF6: implications in NF-kB activation. Adv Exp Med Biol. 691: 89-91

​

Wang L*, Yang J*, Kabaleeswaran V*, Rice A, Cruz A, Park A, Yin Q, Damko E, Jang S, Raunser S, Robinson C, Siegel R, Walz T, Wu H† (2010). The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nature Struct Mol Biol. 17:1324-9

​

LLin SC, Lo YC, Wu H† (2010). Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signaling. Nature. 465: 885-90

​

Zheng C, Kabaleeswaran V*, Wang Y*, Cheng G, Wu H† (2010). Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes -- affinity, specificity and regulation. Mol Cell. 38:101-13

​

Wu H†, Lo YC, Lin SC. (2010). Recent advances in polyubiquitin chain recognition. F1000 Biol Reports. 2:1-5

​

Zheng C, Wu H†. (2010). RIG-I "sees" the 5'-triphosphate. Structure.18:894-6

​

Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich R, Campos A, Myszka D, Lenardo M, Darnay B, Wu H† (2009). E2 interaction and dimerization in the crystal structure of TRAF6. Nature Struct Mol Biol. 16:658-66

​

Lo YC, Lin SC, Rospigliosi C, Conze D, Wu CJ, Ashwell J, Eliezer D, Wu H† (2009). Structural Basis for Recognition of Diubiquitins by NEMO. Mol Cell. 33:602-615

​

Yin Q, Lamothe B, Darnay B, Wu H†. (2009). Structural basis for the lack of E2 interaction in the RING domain of TRAF2. Biochemistry. 48:10558-67

​

Pan W*, da Graca LS*, Shao Y, Yin Q, Wu H, Jiang X†. (2009). PHAPI/pp32 suppresses tumorigenesis by stimulating apoptosis. J Biol Chem. 284:6946-6954

​

Yin Q, Lin SC, Lo YC, Damo S, Wu H. (2009). Tumor Necrosis Factor Receptor- Associated Factors in Immune Receptor Signal Transduction. Handbook of Cell Signaling, edited by Bradshaw. Pages 339-345

​

Wu H*, Hymowitz S*. (2009). Structure and Function of Tumor Necrosis Factor (TNF) at the Cell Surface. Handbook of Cell Signaling, edited by Bradshaw. Pages 265-275

​

Wu H*, Lo YC*. (2009). Structures, domains and functions in cell death (DD, DED, CARD, PYD). In Encyclopedia of Life Sciences. John Wiley & Sons Ltd, Chichester

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Lin SC*, Chung JY*, Lamothe B, Rajashankar K, Lu M, Lo YC, Lam AY, Darnay BG†, Wu H†. (2008). Molecular Basis for the Unique Deubiquitinating Activity of the NF-kappaB Inhibitor A20. J Mol Biol. 376:526-40. Commentary

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Lo YC*, Maddineni U*, Chung JY, Rich RL, Myszka DG, Wu H†. (2008). High-affinity interaction between IKKbeta and NEMO. Biochemistry. 47:3109-16

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Lu M, Lin SC, Huang Y, Kang Y, Rich R, Lo YC, Myszka D, Han J, Wu H† (2007). XIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell. 26:689-702.

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Park H, Logette E, Rauser S, Cuenin S, Walz T, Tschopp J, Wu H† (2007). Death domain assembly mechanism revealed by crystal structure of the oligomeric PIDDosome core complex. Cell. 128:533-546

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Wu H†, Tschopp J, Lin SC. (2007). Smac mimetics and TNFalpha: a dangerous liaison? Cell. 131:655-65

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Lin SC, Huang Y, Lo YC, Lu M, Wu H†. (2007). Crystal Structure of the BIR1 Domain of XIAP in Two Crystal Forms. J Mol Biol. 372:847-854

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Gao Z, Tian Y, Wang J, Yin Q, Wu H, Li YM, Jiang X†. (2007). A dimeric Smac/diablo peptide directly relieves caspase-3 inhibition by XIAP: Dynamic and cooperative regulation of XIAP by Smac/Diablo. J Biol Chem. 282:30718-27

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Park H, Wu, H†. (2007). Crystallization and preliminary X-ray crystallographic studies of the oligomeric death domain complex between PIDD and RAIDD. Acta Crystallogr. F63:229-32

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Besse A, Lamothe B, Campos A, Webster W, Maddineni U, Lin SC, Wu, H, Darnay B†. (2007). TAK1-dependent signaling requires functional interaction with TAB2/TAB3. J Biol Chem. 282:3918-28

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Lamothe B, Besse A, Campos AD, Webster WK, Wu H and Darnay BG†. (2007). Site-specific Lys63-linked TRAF6 auto-ubiquitination is a critical determinant of IKK activation. J Biol Chem. 282:4102-12

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Yan S, Chen X, Wu H. (2007). ABAD: Mitochondrial Target for A!-Mediated Cellular Perturbation in Alzheimer Disease. in Research Progress in Alzheimer's Disease and Dementia, Vol. 3, edited by Miao-Kun Sun. pages 175-189

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Park H, Lo YC, Lin SC, Wang L, Yang J, Wu H. (2007). The Death Domain Superfamily in Intracellular Signaling of Apoptosis and Inflammation. Ann Rev Immunol. 25:561-86

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Yin Q, Park H, Chung J, Lin SC, Lo YC, Graca L, Jiang X, Wu H† (2006). Caspase-9 Holoenzyme Is a Specific and Optimal Procaspase-3 Processing Machine. Mol Cell. 22:259-268.

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Lu M, Min T, Eliezer D, Wu H† (2006). A novel role for native chemical ligation in covalent caspase inhibition by p35. Chemistry and Biology. 13: 117-22. Commentary

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Park H H, Tookes H E, Wu H† (2006). Crystallization and preliminary X-ray crystallographic studies of Drep-3, a DFF-related protein from Drosophila melanogaster. Acta Crystallogr. F62:597-599

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Muppidi J, Lobito A, Yang J K, Wang L, Wu H, Siegel R† (2006). Homotypic FADD interactions though a conserved RXDLL motif are required for death receptor-induced apoptosis. Cell death and differentiation. 13:1641-50

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Guasparri I, Wu H, Cesarman E† (2006). The KSHV oncoprotein vFLIP contains a TRAF-interacting motif and requires TRAF2 and TRAF3 for signaling. EMBO Rep. 7:114-9

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Park H H, Wu H† (2006). Crystal Structure of RAIDD Death Domain Implicates Potential Mechanism of PIDDosome Assembly. J Mol Biol. 357:358-64

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Chung J, Lu M, Yin Q, Lin SC, Wu H† (2006). Molecular basis for the unique specificity of TRAF6. In TNF Receptor Associated Factors, edited by Hao Wu, Pages 122-130

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Chung J, Lu M, Yin Q, Wu H† (2006). Structural revelation of TRAF2 function. In TNF Receptor Associated Factors, edited by Hao Wu. Pages 93-113

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Yang J K*, Wang L*, Zheng L, Wan F, Ahmed M, Lenardo M, Wu H† (2005). Crystal Structure of MC159 Reveals Molecular Mechanism of DISC Assembly and FLIP Inhibition. Mol Cell. 20:939-949 (Cover article)

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Steegborn C, Litvin T N, Levin L R, Buck J, Wu H† (2005). Bicarbonate activation of adenylyl cyclases via promotion of the catalytic cycle: active site closure and metal recruitment. Nature Struct. & Mol. Biol. 12: 32-7. Commentary

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Steegborn C*, Litvin TN*, Hess KC, Capper AB, Taussig R, Buck J, Levin LR, Wu H† (2005). A novel mechanism for adenylyl cyclase inhibition from the crystal structure of its complex with catechol estrogen. J Biol Chem. 280:31754-93

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Lustbader J*, Cirilli M*, Lin C*, Xu H W, Caspersen C, Wang N, Takuma K, Chen X, Chaney M, Trinchese F, Liu S, Kuppusamy P, Zewier Z, Arancio O, Stern D, Yan S D*†, Wu H*† (2004). ABAD-Abeta interaction is a direct link from Abeta to mitochondrial toxicity in Alzheimer's disease. Science. 304:448-452

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Huang Y, Lu M, Wu H†. (2004). XIAP inhibitors for cancer treatment: removing the brakes of apoptosis? Cancer Cell. 5:1-2

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Ye H, Chen T, Xu X, Pennycooke M, Wu H† , Steegborn C† . (2004). Crystal structure of the putative adapter protein MTH1859. J Struct Biol. 148:251-6

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Dzivenu O K, Park H H, Wu H†. (2004). General co-expression vectors for the overexpression of heterodimeric protein complexes in Escherichia coli. Protein Expr Purif. 38: 1-8

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Huang Y, Lu M, Wu H†. (2004). Antagonizing XIAP-mediated caspase-3 inhibition. Achilles' heel of cancers? Cancer Cell. 5:1-2

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Wu H*. (2004). Assembly of post-receptor signaling complexes for the TNF receptor superfamily. Advances in Protein Chemistry. 68:225-79

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Park H H, Wu H†. (2004). Gauging length: recognition of small interfering RNAs. Structure. 12:172-173

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Moldovan MC*, Yachou A*, Levesque K, Wu H, Hendrickson WA, Cohen EA, Sekaly RP†. (2002). CD4 dimers constitute the functional component required for T cell activation. J. Immunology. 169:6261-8

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Xu G, Rich R L, Steegborn C, Min T, Huang Y, Myszka D G, Wu H†. (2003). Mutational Analyses of the p35/caspase Interaction: A bowstring kinetic model of caspase inhibition by P35. J Biol Chem. 278:5455-61

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Huang Y, Rich R, Myszka D, Wu H†. (2003). Requirement of both the BIR2 and BIR3 domains for the relief of XIAP-mediated caspase inhibition by Smac. J Biol Chem. 278:49517-22

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Chung J, Park Y C, Ye H, Wu H. (2003). TNF receptor associated factors. In Handbook of Cell Signaling. 1:311

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Wu H†, Arron J. (2003). TRAF6, a molecular bridge of adaptive immunity, innate immunity and bone homeostasis. Bioessays. 25:1096-1105

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Ye H, Cande C, Stephanou N, Gurgusani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H† (2002). DNA binding as a structural requirement for the apoptogenic action of AIF. Nature Struct Biol. 9:680-4

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Ye H*, Arron J*, Lamothe B, Cirilli M, Kobayashi T, Shvede N, Segal D, Dzivenu O, Vologodskaia M*, Yim M, Du K, Singh S, Pike J W, Darnay B, Choi Y, Wu H† (2002). Distinct molecular mechanism for initiating TRAF6 signaling. Nature. 418:443-7

Ye H, Cirilli M, Wu H†. (2002). The use of construct variation and diffraction data analysis in the crystallization of the TRAF domain of human tumor necrosis factor receptor associated factor 6. Acta Crystallogr D Biol Crystallogr. 58:1886-1888

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Chung J, Park Y C, Ye H, Wu H†. (2002). All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction. J Cell Sci. 115:679-688

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Huang Y*, Park Y C*, Rich R L, Segal D, Myszka D G, Wu H† (2001). Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell. 104:781-790

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Xu G, Cirilli M, Huang Y, Rich R L, Myszka D G, Wu H† (2001). Covalent inhibition revealed by the crystal structure of the p35/caspase-8 complex. Nature. 410:494.

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Park Y C, Ye H, Hsia C, Segal D, Rich R L, Liou H C, Myszka D G, Wu H† (2000). A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell. 101:777-87

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Ye H, Wu H†. (2000). Thermodynamic characterization of the interaction between TRAF2 and tumor necrosis factor receptor peptides by isothermal titration calorimetry. Proc Natl Acad Sci U S A. 97:8961-6

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Ni C Z, Welsh K, Leo E, Chiou C K, Wu H, Reed J C, Ely K R†. (2000). Molecular basis for CD40 signaling mediated by TRAF3. Proc Natl Acad Sci U S A. 97:10395-9

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Ye H, Park Y C, Kreishman M, Kieff E, Wu H† (1999). The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol Cell. 4:321-30

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Park Y C, Burkitt V, Villa A R, Tong L, Wu H† (1999). Structural basis for self-association and receptor recognition of human TRAF2. Nature. 398:533-8

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Wu H, Park Y C, Ye H, Tong L. (1999). Structural studies of human TRAF2. in Cold Spring Harbor Symposium Quant Biol (Signaling and Gene Expression in the Immune System). 64:541-549

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Bhargava G, Mui S, Pav S, Wu H, Loeber G, Tong L†. (1999). Preliminary crystallographic studies of human mitochondrial NAD(P)(+)- dependent malic enzyme. J Struct Biol. 127:72-5

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Xu Y, Bhargava G, Wu H, Loeber G, Tong L†. (1999). Crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme: a new class of oxidative decarboxylases. Structure. 41:6928-38

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Lustbader J W, Lobel L, Wu H, Elliott M M. (1998). Structural and molecular studies of human chorionic gonadotropin and its receptor. Recent Prog Horm. 53:395-424

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H Wu, P D Kwong, W A Hendrickson (1997). Dimeric association and segmental variability in the crystal structure of human CD4. Nature. 387:527-530

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Wu H*, Myszda D G*, Tendian S W, Brouillette C G, Sweet R W, Chaiken I M, Hendrickson W A (1996). Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding. PNAS. 93:15030-15035

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Jiang X, Dreano M, Buckler D R, Cheng S, Ythier A, Wu H, W A Hendrickson, Tayar N E.† (1995). Structural predictions for the ligand-binding region of glycoprotein hormone receptors and the nature of hormone-receptor interactions. Structure. 3:1341-1353

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Lustbader J W, Wu H, Birken S, Pollak S, Kolks M A G, Pound A M, Austin D, Hendrickson W A, Canfield R E. (1995). The expression, characterization and crystallization of wild-type and selenomethionyl hCG. Endocrinology. 136:640-650

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Wu H, Lustbader J, Liu Y, Canfield R, Hendrickson W† (1994). Structure of human chorionic gonadotropin at 2.6 Å resolution from MAD analysis of the selenomethionyl protein. Structure. 2:545-558. (News & Views in Nature, 369: 438-439, 1994)

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Lustbader J W, Wang C, Zhang X, Birken S, Wu H, Brown J M, Yarmush D, Pollak S, Canfield R E. (1994). Human chorionic gonadotropin: progress in determining its tertiary structure. Glycoprotein hormones. pp 81-102. Springer-Verlag, New York

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Wu H, Keller W, Rossmann M G† (1993). Determination and refinement of the canine parvovirus empty capsid structure. Acta Crystallogr. D49:572-579

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Wu H, Rossmann M G.† (1993). The canine parvovirus empty capsid structure. J Mol Biol. 233: 231-244

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Tsao J, Chapman M S, Wu H, Agbandje M, Keller W, Rossmann M G. (1992). The structure determination of monoclinic canine parvovirus. Acta Crystallogr. B48:75-88

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Rossmann M G†, McKenna R, Tong L, Xia D, Dai J, Wu H, Choi H, Lynch R E. (1992). Molecular replacement real space averaging. J. Appl. Crystallogr. 25:166-180

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Gong Z X, Wu H, Cheng R H, Hull R, Rossmann M G† (1990). Crystallization of cauliflower mosaic virus. Virology. 179:941-5

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